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한국자원식물학회 / v.8, no.3, 2005년, pp.209-216 
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( Anti Angiogenic Effects of Isorhamnetin Isolated from Persicaria thunbergii ) |
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| 초 록 |
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| Persicaria thunbergii has been utilized for the treatment of cancer as a folk medicine. We examined the effect of isorhamnetin, a flavonoid isolated from Persicaria thunbergii, on angiogenesis in vitro and in vivo. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor found in various tumors. In this study, we found that the isorhamnetin decreased bFGF-induced human umbilical vein endothelial cells (HUVECs) proliferation and migration in a concentration-dependent manner (5, 10 and $20;{mu}M$) whereas, it did not inhibit bFGF-induced capillary-like formation of HUVECs. The chicken chorioallantoic membrane assay revealed that addition of isorhamnetin (10, 20 and $40;{mu}M$) displayed an antiangiogenic effect in vivo. These results suggest that the isorhamnetin inhibits the proliferation and migration of endothelial cells induced by bFGF, which may explain its anti-angiogenic properties. |
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| 키워드 |
| isorhamnetin;angiogenesis;Persicaria thunbergii; |
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Plant Resources / v.8, no.3, 2005년, pp.209-216
한국자원식물학회
ISSN : 1226-8771
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200517033413588)
언어 : 영어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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