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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.14, no.1, 2001³â, pp.32-37
ÇѾàÀç·ÎºÎÅÍ Tyrosinase ÀúÇØÁ¦ÀÇ Å½»ö
( Screeing of Tyrosinase Inhibitors from Oriental Herbs )
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ÇѾàÀç 174Á¾À¸·ÎºÎÅÍ tyrosinase ÀúÇØÁ¦¸¦ Ž»öÇÏ¿´´Ù. ÇѾàÀç´Â 30Àϰ£ methanol¿¡ ´ã°¡ ³õÀº ÈÄ, ±× ÃßÃâ¾×À» Á¦Á¶ÇÏ¿© »ç¿ëÇÏ¿´´Ù TyrosinaseÀÇ È°¼ºÀ» ÃøÁ¤Çϱâ À§Çؼ­´Â È¿¼Ò mushroom Tyrosinase¿Í ±âÁú L-DOPA, phosphate buffer¸¦ »ç¿ëÇÏ¿´´Ù. Ž»ö °á°ú, ÇѾàÀç 174Á¾ Áß 14°³Á¾ÀÌ tyrosinase¸¦ ÀúÇØ È¿°ú¸¦ º¸¿´°í, ±×Áß ¿À¹èÀÚ ÃßÃâ¾×ÀÌ inhibition activity°¡ °¡Àå ³ô°Ô ³ªÅ¸³µ´Ù.
Mammalian tyrosinase plays an important role in the process of melanin polymer biosynthesis by catalyzing the hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine(DOPA) and the oxidation of DOPA to dopaquinone. These processes are major determinant of human skin color and involved in localized hyperpigmentation. Therefore, the enzyme inhibitors have been of great concern as skin-whitening cosmetics. Methanol extracts of 174 oriental herbs were screened for the mushroom tyrosinase inhibitory activity.
 
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inhibition;extracts;melanin;skin;DOPA;
 
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.14, no.1, 2001³â, pp.32-37
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200111921402892)
¾ð¾î : Çѱ¹¾î
³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø
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