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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.20, no.4, 2007³â, pp.362-366
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( Anti-diabetic Effect of the Methanolic Extract of Ligularia stenocephala Leaves in the Streptozotocin-induced Rat )
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°ï´Þºñ ¸Þź¿Ã ÃßÃâ¹°Àº 100mg/kg ¹× 200mg/kgÀÇ °æ±¸Åõ¿©·Î STZ·Î À¯µµµÈ ´ç´¢º´ÀÇ Á¦¹Ý Áõ»óÀ» ¿ÏÈ­ÇÏ¿´´Ù. Áï, STZÀÇ Åõ¿©´Â ÈòÁãÀÇ Ã¼Áß, ¼öºÐ ¼·Ãë, ½ÄÀ̼·Ã븦 Áõ°¡½ÃÄ×À¸¸ç, Ç÷´ç·®, Ç÷û triglyceride ·®, µ¿¸Æ°æÈ­ À§ÇèÁö¼ö¸¦ Áõ°¡½ÃÄ×À¸³ª, °ï´Þºñ ÃßÃâ¹°ÀÇ Åõ¿©´Â ÀÌ·¯ÇÑ ´ç´¢º´¿¡ °ü·ÃµÈ Áõ»óÀ» °³¼±ÇÏ¿´´Ù. ÀÌ¿Í ´õºÒ¾î, À§ÀÇ ´ç´¢º´ ¸ðµ¨ Áã¿¡¼­ ´ç³»¼º ½ÇÇè¿¡¼­µµ °ï´Þºñ ÃßÃâ¹°ÀÌ ÇöÀúÇÑ È¿°ú¸¦ ³ªÅ¸³»¾úÀ¸¹Ç·Î Ç÷´çÀÇ ¼¼Æ÷³» ÀÌÇàÀ» ÃËÁø½ÃŰ´Â °ÍÀ¸·Î È®ÀεǾú´Ù. ÀÌ»ó°ú °°Àº °á°ú·ÎºÎÅÍ °ï´Þºñ ÃßÃâ¹°Àº ´ç´¢º´ ¹× ±×¿¡ µû¸£´Â °íÁöÇ÷Áõ¿¡ À¯È¿ÇÏ¿´À¸¹Ç·Î ´ç´¢º´ ÁúȯÀÇ ¿ÏÈ­¸¦ À§ÇÏ¿© »ç¿ëµÉ ¼ö ÀÖ´Â »êä ½ÄǰÀÎ °ÍÀ¸·Î ³ªÅ¸³µ´Ù. ÀÌ·¯ÇÑ °á°ú¸¦ ¹ÙÅÁÀ¸·Î °ï´ÞºñÀÇ È°¼º ¹°ÁúÀÇ ÀÔÁõ°ú ±× À̿뿡 °üÇÑ °è¼ÓÀûÀÎ ¿¬±¸°¡ ÇÊ¿äÇÑ °ÍÀ¸·Î »ý°¢µÈ´Ù.
The leaves of Ligularia stenocephala (Compositae) are used as a vegetable food to treat anxiety, weakness and menstrual disorder and are said to be effective against diabetic disease in Korea. This research was aimed to develop this vegetable food as a functional food to treat diabetic disease. Oral administration of MeOH extract exhibited significant hypoglycemic and hypolipidemic effects in streptozotocin (STZ)-induced diabetic rats at 100 and 200 mg/kg dose. This extract inhibited the increase of body weight, water consumption, food intake, blood glucose, lowered atherogenic index, and overcome glucose intolerance in the STZ-treated rat. These results suggest that the leaves of Ligularia stenocephala could be developed as a functional food with anti-diabetic effect.
 
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Ligularia stenocephala;Compositae;Diabetic;Functional food;Vegetable;
 
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.20, no.4, 2007³â, pp.362-366
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200736038131742)
¾ð¾î : Çѱ¹¾î
³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø
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