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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.21, no.1, 2008³â, pp.91-95
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»óȲ¹ö¼¸ ÃßÃâ¹°ÀÇ Ç×»êÈ È¿°ú
( Antioxidative Effects of Phellinus linteus Extract ) |
| ·ùµ¿¿µ;±è¹Î¼®;¹Î¿ÀÁø;±èµ¿¿í; ¸ñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкθñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкΠ»ý¾àÀÚ¿ø;¸ñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкθñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкΠ»ý¾àÀÚ¿ø;¸ñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкθñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкΠ»ý¾àÀÚ¿ø;¸ñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкθñÆ÷´ëÇб³ ÀÚ¿¬°úÇдëÇÐ »ý¸í°úÇкΠ»ý¾àÀÚ¿ø;
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| º» ¿¬±¸¿¡¼´Â ${O_2}^-,{cdot}OH$ radical, NO, $ONOO^-$ ÀÚÀ¯¶óµðÄ®À» À¯¹ß½ÃŰ´Â in vitro assay system°ú free radical-induced oxidative stress¿¡ ÀÇÇÑ ´Ü¹éÁú ¼Õ»ó¿¡ ´ëÇÑ ÁøÈë¹ö¼¸¼Ó¿¡ ¼ÓÇÏ´Â »óȲ¹ö¼¸ ¹° ÃßÃâ¹°ÀÇ Ç×»êÈ È¿°ú¸¦ ÃøÁ¤ÇÏ¿´´Ù. »óȲ¹ö¼¸ ¹° ÃßÃâ¹°ÀÇ ${O_2}^-,{cdot}OH$ radical, NO, $ONOO^-$ ÀÚÀ¯¶óµðÄ® ¾ïÁ¦È¿°ú¿¡¼´Â ½ÇÇè¿¡ »ç¿ëµÈ ¾ç¼º ´ëÁ¶¹° º¸´Ù´Â ³·°Ô ³ªÅ¸³µÀ¸³ª ¸ðµç ½ÇÇè°è¿¡¼ ´ëÁ¶±º¿¡ ºñÇØ ¶Ñ·ÇÇÏ°Ô ÀÚÀ¯¶óµðÄ® ¼Ò°ÅÈ¿°ú¸¦ ³ªÅ¸³Â´Ù. ¶ÇÇÑ »óȲ¹ö¼¸ ¹° ÃßÃâ¹°Àº »êÈÀû ½ºÆ®·¹½º¿¡ ÀÇÇÑ ´Ü¹éÁú ¼Õ»ó ¾ïÁ¦È¿°ú¿¡¼µµ ´ëÁ¶±º¿¡ ºñÇØ ¸íÈ®ÇÑ ÀúÇØÈ¿°ú¸¦ ³ªÅ¸³Â´Ù. ±×·¯¹Ç·Î »óȲ¹ö¼¸ÀÇ Ç×»êÈ È¿°ú´Â »óȲ¹ö¼¸ÀÇ ¾à¸®ÇÐÀû È¿´ÉÀ» ¼³¸íÇϴµ¥ Áß¿äÇÑ ±âÃÊ ÀÚ·á¶ó°í »ç·áµÈ´Ù. |
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| Reactive oxygen species(ROS) or free radical-mediated oxidative stress plays an important role in the pathophysiologic process of disease state. This study investigated antioxidative effects of Phellinus linteus extract on the generation of 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical, superoxide anion radical(${O_2}^-$), hydroxyl radical(${cdot}OH$), nitric oxide(NO), and peroxynitrite($ONOO^-$) radical and free radical-mediated protein oxidation under in vitro assay systems. This results showed that Phellinus linteus extract effectively inhibited the generation of free radicals in the all assay system with dose-dependent manner and also significantly reduced the protein oxidative level. Thus, the present study indicates that Phellinus linteus extract possesses a potent antioxidant activity and plays a beneficial role against free radical-induced oxidative injury. |
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| Ű¿öµå |
| Antioxidant;Free radical;Oxidative stress;Phellinus linteus;Reactive oxygen species(ROS); |
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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.21, no.1, 2008³â, pp.91-95
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200810737156854)
¾ð¾î : Çѱ¹¾î |
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| ³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø |
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