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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.7, no.1, 1994³â, pp.89-95

( Preparation and Antileukemic Activity of Congeners of Tropoloisoquinoline Alkaloids from Abuta Concolor )
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Antileukemic tropoloisoquinoline alkaloids, pareirubine A (1) and gandirubrine (2), at first have been isolated from.Abuta concolor (Menisper-maceae). Methylation of 1 and 2, existing in solution as a mixture of tautomersgave the corresponding four methyl derivatives (3 -6). Thioimerubrine (7) andthioisoimerubrine (8) were prepared by the nucleophilic substitutions of themethoxyl groups at C-11 and -10, respectively. Acetylation of 1 and 2produced the corresponding mono-acetyl tautomers (9 and 10). Antileukemicactivity of these derived tropoloisoquinoline alkaloids is also reported.
 
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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.7, no.1, 1994³â, pp.89-95
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ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO199411920277812)
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