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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.21, no.4, 2008³â, pp.254-259
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¾à¿ë½Ä¹°ÀÇ Peroxynitrite¿Í Hydroxyl radical ¼Ò°Å Ȱ¼º
( Peroxynitrite and Hydroxyl Radical Scavenging Activity of Medicinal Plants ) |
| ¹Î¿ÀÁø;±è¹Î¼®;°ûº´Èñ;·ùµ¿¿µ; ¸ñÆ÷´ëÇб³ »ý¸í°úÇкΠ»ý¾àÀÚ¿øÀü°ø;¸ñÆ÷´ëÇб³ »ý¸í°úÇкΠ»ý¾àÀÚ¿øÀü°ø;¸ñÆ÷´ëÇб³ »ý¸í°úÇкΠ»ý¾àÀÚ¿øÀü°ø;¸ñÆ÷´ëÇб³ »ý¸í°úÇкΠ»ý¾àÀÚ¿øÀü°ø;
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| ¾à¿ë½Ä¹° 9Á¾ÀÇ ¹° ÃßÃâ¹°¿¡ ´ëÇÑ Ç×»êÈ È¿°ú¸¦ Ž»öÇϱâ À§ÇØ in vitro Á¶°Ç¿¡¼ °·ÂÇÑ »êȷ°ú µ¶¼ºÀ» °®´Â $ONOO^-$¿Í ${cdot}$OH radicalÀÇ ¼Ò°ÅÈ¿°ú¸¦ ÃøÁ¤ÇÏ¿´´Ù. ±× °á°ú, °¨ÀÙ, ±¸±âÀÚ, ²ÙÁö»Í³ª¹«, ´ãÀïÀ̵¢±¼, ¸¶µðÇ®, ºñÆÄ³ª¹«, À¸¸§µ¢±¼, ÂüÃë ÃßÃâ¹°Àº 10${mu}g/ml$ ³óµµ¿¡¼ 50% ÀÌ»óÀÇ$ONOO^$ ¼Ò°ÅÈ¿°ú¸¦ ³ªÅ¸³Â´Ù. ÀÌ·¯ÇÑ $ONOO^-$ ¼Ò°ÅÈ¿°ú´Â ¾ç¼º ´ëÁ¶¹°ÀÎ penicillamine(94.08${pm}$3.04)¿¡ ºñÇØ ³·¾ÒÁö¸¸ ºñÆÄ³ª¹« ¹° ÃßÃâ¹°(89.87${pm}$4.57)ÀÌ ´Ù¸¥ ½Ã·á¿¡ ºñÇØ °¡Àå °·ÂÇÑ $ONOO^-$ ¼Ò°ÅÈ¿°ú¸¦ ³ªÅ¸³Â´Ù. ¶ÇÇÑ, °¡´ÂÀÙ½û±âÇ®°ú °¨ÀÙ ¹° ÃßÃâ¹°Àº 1mg/ml ³óµµ¿¡¼ ¾ç¼º´ëÁ¶¹°ÀÎ thiourea º¸´Ù È¿°úÀûÀÎ${cdot}$OH radical ¾ïÁ¦È¿ °ú¸¦ ³ªÅ¸³Â´Ù. °á·ÐÀûÀ¸·Î 9Á¾ÀÇ ¾à¿ë½Ä¹°Àº $ONOO^-$¿Í${cdot}$OH radical°ú ¿¬°üµÈ »êÈÀû ½ºÆ®·¹½º¿¡ ÀÇÇÑ ¼¼Æ÷¿Í Á¶Á÷ÀÇ ¼Õ»óÀ» ¾ïÁ¦½Ãų ¼ö Àִ õ¿¬ Ç×»êÈÁ¦·Î ¹àÇôÁ³´Ù. |
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| The radical scavenging activities of 9 medicinal plants on peroxynitrite ($ONOO^-$) and hydroxyl (${cdot}OH$) radical were investigated using in vitro system. The water extracts of 9 medicinal plants showed the protective effect against $ONOO^-$ and ${cdot}OH$ radical. In particular, Akebia quinata, Aster scaber, Cudrania tricuspidata, Diospyros kaki, Eriobotrya japonica, Lycium chinense, Parthenocissus tricuspidata and Polygonum aviculare exhibited $ONOO^-$-scavenging activity by about 50% at the concentration of $10{mu}g/ml$. Although those $ONOO^-$-scavenging activities were lower than that of penicillamine (94.08${pm}$3.04%) as a positive control, Eriobotrya japonica (89.87${pm}$4.57%) was the most potent scavenger of $ONOO^-$ at the concentration of $10{mu}g/ml$. Also, Diospyros kaki and Urtica angustifolia showed the strong${cdot}$OH-scavenging activity than thiourea, positive control, at the concentration of lmg/ml. Our results indicate that 9medicinal plants may act as free radical scavengers and reduce damages caused by oxidative stress associated with $ONOO^-$ and${cdot}$OH radical. |
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| Ű¿öµå |
| Medicinal plant;Peroxynitrite;Hydroxyl radical;Free radical scavenger;Oxidative stress; |
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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.21, no.4, 2008³â, pp.254-259
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200831050534482)
¾ð¾î : Çѱ¹¾î |
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| ³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø |
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