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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.21, no.4, 2008³â, pp.265-269
¸ÓÀ§(Petasites japonicus) ÃßÃâ¹°ÀÇ Ç×»êÈ­¿Í Ç×¾ÏȰ¼º È¿°ú
( The Antioxidant and Anticancer Effects of Butterbur (Petasites japonicus) Extracts )
¼­ÈƼ®;Á¤ºÀȯ;Á¶¿ë±¸; ÃæºÏ´ëÇб³ ³ó¾÷»ý¸íȯ°æ´ëÇÐ ½Ä¹°ÀÚ¿øÇаú;¼­¿ø´ëÇб³ ģȯ°æ ¹ÙÀÌ¿À¼ÒÀç ¹× ½Äǰ¼¾ÅÍ;ÃæºÏ´ëÇб³ ³ó¾÷»ý¸íȯ°æ´ëÇÐ ½Ä¹°ÀÚ¿øÇаú;
 
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¸ÓÀ§ÀÇ »Ñ¸®, ÁÙ±â, ÀÙÀ» »ç¿ëÇÏ¿© ÃßÃâ¹°¿¡ µû¸¥ Ç×»êÈ­ Ȱ¼ºÀ» ºÐ¼®ÇÏ¿´°í, ÃßÃâ¹°À» ºÐȹ Á¤Á¦ÇÏ¿© ¾Ï¼¼Æ÷ »ýÀå ¾ïÁ¦¼ºÀ» ½ÇÇèÇÏ¿´´Ù. SOD À¯»çȰ¼ºÀº ¸ÓÀ§ ÀÙÀÇ ¿¡Åº¿Ã ÃßÃâ¹°ÀÌ 96.7%ÀÇ °¡Àå ³ôÀº Ȱ¼ºÀ» º¸¿´À¸¸ç, ÃßÃâ ¿ë¸Å¿¡ µû¸¥ ¸ÓÀ§ÀÇ SOD À¯»çȰ¼ºÀº ¹° ÃßÃ⺸´Ù´Â ¿¡Åº¿Ã ÃßÃâ¹°ÀÌ ´õ¿í ³ôÀº Ç×»êÈ­ Ȱ¼ºÀ» ³ªÅ¸³Â´Ù. ÃÑÆú¸®Æä³î ÇÔ·®Àº ¹° ÃßÃâ¹°¿¡¼­ ÀüüÀûÀ¸·Î ³ôÀº ÇÔ·®À» ³ªÅ¸³»¾úÀ¸¸ç, ¸ÓÀ§ ÀÙÀÌ 223mg/g dry weightÀ¸·Î °¡Àå ³ô¾Ò´Ù. ½Ã·áº°·Î ÀüÀÚ°ø¿©´É È¿°ú¸¦ »ìÆìº¸¸é ¸ÓÀ§ »Ñ¸®ÀÇ ¹° ÃßÃâ¹°¿¡¼­ 61.5%, ¸ÓÀ§ ÀÙÀÇ ¿¡Åº¿Ã ÃßÃâ¹°¿¡¼­ 34.9%·Î °¡Àå ³ôÀº ÀüÀÚ°ø¿©´ÉÀ» ³ªÅ¸³Â´Ù. ¾Ï¼¼Æ÷ »ýÁ¸ ¾ïÁ¦¼ºÀÇ ½ÇÇè¿¡¼­ ¸ÓÀ§ ÃßÃâ¹°ÀÇ ºÐȹ¹°µéÀº Á¤»ó¼¼Æ÷ DC2.4ÀÇ »ýÀ°¿¡´Â Å©°Ô ¿µÇâÀ» ¹ÌÄ¡Áö ¾ÊÀ¸¸é¼­µµ À§¾Ï¼¼Æ÷ÁÖ SNU-719ÀÇ »ýÀ°Àº 41.9%·Î Å©°Ô ¾ïÁ¦½ÃÄ×°í, °£¾Ï¼¼Æ÷ÁÖ Hep3BÀÇ »ýÀ°Àº 72.7% ¾ïÁ¦½ÃÄ×´Ù. º» ¿¬±¸ °á°úµéÀ» Á¾ÇÕÇØ º¼ ¶§ ¸ÓÀ§¸¦ ÀÌ¿ëÇÑ »õ·Î¿î ±â´É¼º ½Äǰ ¼ÒÀç ¹× ¾à¿ëÀÚ¿ø½Ä¹°·Î °³¹ßÀÌ °¡´ÉÇÏ´Ù.
The antioxidant activities of the extracts of butterbur (Petasites japonicus) derived from different extraction methods were investigated. SOD (superoxide dismutase)-like activity differed according to the extraction solvents, showing a greater antioxidant effect with ethanol solvent than that of water. Ethanol extracts of butterbur leaves showed higher SOD-like activity of 96.7% than those of water extracts. The contents of polyphenolic compounds were higher in water extracts than those in ethanol extracts. The highest content of polyphenolic compounds was 223mg/g dry weight for butterbur leaves. EDA of butterbur roots was 61.5% in the water extract and EDA in butterbur leaves was 34.9% in the ethanol extract. The anticancer effects with the extracts of butterbur were experimented by fractionations with different solvents. 41.9% of the growth of stomach cancer cells, SNU-719, were inhibited and also 72.7% of the growth of liver cancer cells, Hep3B, were inhibited by the butanol fractions of butterbur, while not affecting the growth of normal cell, DC 2.4.
 
Ű¿öµå
SOD-like activity;EDA (electron donating ability);Polyphenol;Anticancer;Stomach cancer;Liver cancer;
 
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.21, no.4, 2008³â, pp.265-269
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200831050534488)
¾ð¾î : Çѱ¹¾î
³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø
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