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한국자원식물학회 / v.22, no.4, 2009년, pp.312-316 
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고련피 추출물의 항암활성
( Anti-cancer Activities of Extract from the Bark of Melia azedarach L. var. japonica Makino ) |
| 김현우;강세찬; 세명대학교 천연자원의약연구소;세명대학교 천연자원의약연구소;
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| 초 록 |
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| In the present study, the anti-cancer activity of 80% ethanol extracts from 120 kinds of medicinal herbs and native plants were investigated. Among them, the barks of Melia azedarach L. var. japonica Makino showed the highest cytotoxicity in HCT-15 human colon cancer cell. With this result, we carried out hollow fiber (HF) assay and anti-metastasis study to confirm the anti-cancer effects of M. azedarach var. japonica. In MTT assay, M. azedarach var. japonica.inhibited the proliferation of HCT-15 cells in dose-dependent manner. HF assay was carried out using A549 human adenocarcinoma cell, HCT-15 and SK-Hep1 human liver cancer cell via intraperitoneal (IP) and subcutaneous (SC) site. As a results, SK-Hep1 implanted in IP site showed the highest cytotoxicity. The result from metastatic model using B16/BL6 mouse corresponded to that of HF assay. These results suggest that the ethanol extract from M. azedarach var. japonica. might have a potent anti-cancer activity and advanced study is needed for the development of novel natural anti-cancer drug. |
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| 키워드 |
| Anti-cancer;human cancer cell;HF assay;metastasis;Melia azedarach L. var. japonica Makino; |
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한국자원식물학회지 / v.22, no.4, 2009년, pp.312-316
한국자원식물학회
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200928038434657)
언어 : 한국어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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