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한국자원식물학회 / v.23, no.6, 2010년, pp.487-497 
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( Inhibitory Effect of the Phenolic Compounds from Apples Against Oxidative Damage and Inflammation ) |
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| 초 록 |
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| ROS have been associated with pathogenic processes including carcinogenesis through direct effect on DNA and play an important role in the pathogenesis of inflammation. Because of many types of phenolic acid derivatives and flavonoids, apples have been one of the human diet since ancient times and are one of the most commonly consumed fruits in worldwide. In this study, catechin, chlorogenic acid and phlorizin dihydrate were purified and identified by HPLC and GC/MS. The contents of catechin, chlorogenic acid and phlorizin dihydrate were 1.01 mg, 7.01 mg and 3.67 mg/ kg wet weight, respectively. Catechin and phlorizin dihydrate were found to significantly inhibit oxidative DNA damage, while chlorogenic did not affect. Also, catechin inhibits NO and $PGE_2$ production via suppressing iNOS and COX-2 expression. However, chlorogenic acid and phlorizin dihydrate did not affect. Our results show that catechin may be the most active phenolic compound in anti-oxidative damage and anti-inflammatory effect. |
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| 키워드 |
| Apple;Phenolic compounds;Reactive oxygen species (ROS);Anti-oxidative damage;Anti-inflammatory effect; |
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한국자원식물학회지 / v.23, no.6, 2010년, pp.487-497
한국자원식물학회
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO201006159731810)
언어 : 영어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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