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한국자원식물학회 / v.23, no.6, 2010년, pp.498-502 
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( Effects of $eta$-glucans from Coriolus versicolor on Macrophage Functions in Young and Aged mice ) |
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| 초 록 |
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| The immune system may play an important role in aging and the changes in the immune status are associated with treatment of various immunomodulators. This study examined the effects of $eta$-glucans isolated from mushroom fungi, Coriolus versicolor on macrophages functions in young (8-weeks-old) and aged (82-weeks-old) male C57BL/6 mice. When peritoneal macrophages were treated with various concentrations of $eta$-glucan ($1-100;{mu}g/ml$) for 24 hrs, tumoricidal activity, NO production and phagocytic activity were significantly increased in the young mice, whereas there are no effects in the aged mice. These results suggest that $eta$-glucans has differential effects on the macrophage functions in young and aged mice and age nutrition might need to be considered to select proper immunomodulator. In addition, $eta$-glucan could be used clinically for the treatment of diseases such as cancer therapy in the young. |
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| 키워드 |
| Beta-glucan;Corious versicolor;Aging;Macrophages; |
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한국자원식물학회지 / v.23, no.6, 2010년, pp.498-502
한국자원식물학회
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO201006159731812)
언어 : 영어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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