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한국자원식물학회 / v.23, no.6, 2010년, pp.513-518 
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( The Analgesic Effect and Mechanisms of Dianthus chinensis L Extract in the mice. ) |
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| 초 록 |
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| In the present study, the antinociceptive profiles of Dianthus chinensis L extract were examined in ICR mice. Dianthus chinensis L extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Dianthus chinensis L extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7;{mu}g$) was diminished by Dianthus chinensis L extract. Intraperitoneal (i.p.) pretreatment with yohimbine ($alpha_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Dianthus chinensis L extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Dianthus chinensis L extract in the writhing test. Our results suggest that Dianthus chinensis L extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Dianthus chinensis L extract may be mediated by $alpha_2$-adrenergic receptor, but not opioidergic and serotonergic receptors. |
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| 키워드 |
| Dianthus chinensis L;Anti-nociception;Inflammatory pain;$alpha_2$ adrenoceptor; |
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한국자원식물학회지 / v.23, no.6, 2010년, pp.513-518
한국자원식물학회
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO201006159731816)
언어 : 영어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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