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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.24, no.1, 2011³â, pp.23-29
Æ«¸³(Liriodendron tulipifera) ³ª¹«°¡Áö ¸Þź¿Ã ÃßÃâ¹°ÀÇ Ç×»êÈ­¿Í Ç×¾ÏȰ¼º È¿°ú
( The Antioxidant and Anticancer Effects of MeOH Extract of Liriodendron tulipifera )
Çã¸í·Ï;¿Õ¶õ;¿Õ¸íÇö; Çϳ²°úÇбâ¼úÇпø;°­¿ø´ëÇб³ ÀÇ»ý¸í°úÇдëÇÐ;°­¿ø´ëÇб³ ÀÇ»ý¸í°úÇдëÇÐ;
 
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º» ¿¬±¸´Â »õ·Î¿î ±â´É¼º ¼ÒÀ縦 Ž»öÇϱâ À§ÇÏ¿© Æ«¸³³ª¹« °¡ÁöÀÇ ¸Þź¿Ã ÃßÃâ¹°À» Á¶Á¦ÇÏ¿© »ý¸®È°¼º ¹°Áú ÇÔ·®, DPPH, ȯ¿ø´É·Â, $Fe^{2+}$ chelatingÈ¿°ú¿Í ÁöÁú°ú»êÈ­ ¾ïÁ¦ Ȱ¼º ±×¸®°í ¼¼Æ÷µ¶¼ºÀ» ÃøÁ¤ÇÏ¿´´Ù. ÃÑ Æä³î¼º È­ÇÕ¹°°ú Çö󺸳ëÀ̵å ÇÔ·®Àº 75.34 mg gallic acid/g°ú 20.15 mg quercetin/gÀ̰í; DPPH ¶óµðÄ® ¼Ò°Å Ȱ¼º¿¡¼­ $EC_{50}$Àº $289.68{pm}2.04 ;{mu}g$/mL; ȯ¿ø·Â ÃøÁ¤¿¡¼­ $100;{mu}g$/mL ³óµµ¿¡¼­ Èí±¤µµ´Â 0.388À̾úÀ¸¸ç, $Fe^{2+}$ chelating È¿°ú¿¡¼­´Â $200;{mu}g$/mL ³óµµ¿¡¼­ 36.33%·Î ³ªÅ¸³»¾ú°í, ÁöÁú°ú»êÈ­ ¾ïÁ¦ È¿´É¿¡¼­´Â $200;{mu}g$/mLÀÇ ³óµµ¿¡¼­ ºñ±³Àû ³ôÀº 38.56%ÀÇ ¾ïÁ¦À²À» ³ªÅ¸³»¾úÀ¸¸ç, ¾Ï¼¼Æ÷ Áõ½Ä ¾ïÁ¦ È¿°ú¿¡¼­´Â HT-29¿Í Hela cell line¿¡¼­ Æ«¸³³ª¹«°¡Áö ¸Þź¿Ã ÃßÃâ¹°ÀÌ $200;{mu}g$/mLÀÇ ³óµµ¿¡¼­ 56.94%¿Í 35.73%ÀÇ ¼¼Æ÷»ýÀå ¾ïÁ¦À²À» ³ªÅ¸³»¾ú´Ù. µû¶ó¼­ º» ¿¬±¸ °á°úµéÀ» Á¾ÇÕÇØ º¼ ¶§ Ç×»êÈ­´É·ÂÀº ÃÑ Æä³î¼ººÐ°ú ¹ÐÁ¢ÇÑ °ü°è°¡ ÀÖ´Â °ÍÀ¸·Î »ç·áµÇ¸ç, Æ«¸³³ª¹« °¡Áö¿¡ ´ëÇÑ ±âŸ »ý¸®È°¼º ¿¬±¸°¡ ´õ ÇÊ¿äÇÒ °ÍÀ¸·Î »ç·áµÈ´Ù.
In order to screen the functional constituents from nature resource, we studied the bioactivities of methanol extract of the Liriodendron tulipifera branch(MLT). The total phenolic and flavonoid contents, DPPH radical scavenging capacity, reducing power, $Fe^{2+}$ chelating ability, inhibition of lipid peroxidation and cell toxicity of MLT were investigated in this study. We found that the total phenolic and flavonoid content of MLT is 75.34 mg gallic acid/g and 20.15 mg quercetin/g respectively. MLT exhibited the antioxidant activity on DPPH radical with a $EC_{50}$ value of $289.68;{mu}g$/mL, the absorbance is 0.388 at $100;{mu}g$/mL in reducing power assay, MLT prevented 38.56% lipid peroxidation at $200;{mu}g$/mL. Furthermore, MLT exhibits the potent anti-proliferative activity which inhibited 56.94%, 35.73% growth of HT-29 and Hela cell at $200;{mu}g$/mL respectively. It showed that the antioxidant activities of MLT were correlated with its total phenolic and flavonoid contents. However further study need to be exploring in the future.
 
Ű¿öµå
Liriodendron tulipifera;Antioxidant;Anticancer;Anti-lipid peroxidation;
 
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.24, no.1, 2011³â, pp.23-29
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO201116450097513)
¾ð¾î : Çѱ¹¾î
³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø
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