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Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ / v.24, no.1, 2011³â, pp.55-60
¾¸¹Ù±ÍÀÇ ÁöÁú°­ÇÏ ¹× Ç×»êÈ­È¿°ú
( Effects of Ixeris dentata ext. on Lowering Lipid and Anti-oxidation )
ÀÌÀº; »óÁö´ëÇб³ º¸°Ç°úÇдëÇÐ Á¦¾à°øÇаú;
 
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¾¸¹Ù±ÍÃßÃâ¹°ÀÌ ºñ¸¸À» À¯µµÇÑ ÈòÁãÀÇ ÁöÁú°­ÇÏ ¹× Ç×»êÈ­ È¿°ú¿¡ ¹ÌÄ¡´Â ¿µÇâÀ» °ËÅäÇÏ¿´´Ù. Ç÷Àå À¯¸®Áö¹æ»ê°ú triglyceride³óµµ´Â ´ëÁ¶±º°ú ºñ±³ÇÏ¿© ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±ºÀº ³óµµ ÀÇÁ¸ÀûÀ¸·Î ³·Àº °ªÀ» ³ªÅ¸³»¾ú´Ù. Ç÷Àå ³» total cholesterol ³óµµ¿Í LDL-cholesterol ³óµµ´Â ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±º ¸ðµÎ¿¡¼­ °¨¼ÒÇÏ´Â °æÇâÀ» º¸¿´´Ù. ±×·¯³ª, HDL-cholesterol³óµµ´Â 󸮱º µé °£¿¡ À¯ÀÇÇÑ Â÷À̸¦ ³ªÅ¸³»Áö ¾Ê¾Ò´Ù. °£Àå total cholesterol°ú triglyceride·®Àº ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±º µéÀÌ ´ëÁ¶±ºº¸´Ù ³·Àº °ªÀ» ³ªÅ¸³»¾ú´Ù. Ç÷Àå ¹× °£ÀåÀÇ TBARS ³óµµ´Â ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±º µé ¸ðµÎ°¡ ´ëÁ¶±ºº¸´Ù À¯ÀÇÇÏ°Ô ³·Àº °ªÀ» ³ªÅ¸³»¾ú´Ù. GSH-Px, SOD ¹× CATÀÇ È°¼ºÄ¡´Â ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±º µéÀÌ ´ëÁ¶±ºº¸´Ù ³ôÀº °ªÀ» ³ªÅ¸³»¾ú´Ù. TNF-${alpha}$, Apo-B, Apo-E ¹× LeptinÀÇ gene expressionÀº ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±ºÀÌ ´ëÁ¶±ºº¸´Ù ³·Àº expressionÀ» ³ªÅ¸³»¾ú´Ù. ${eta}$-actin expression¿¡ ´ëÇÑ TNF-${alpha}$, Apo-B, Apo-E ¹× LeptinÀÇ gene expressionÀÇ ºñÀ²Àº TNF-${alpha}$¿Í Apo-E´Â ´ëÁ¶±ºº¸´Ù ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±º µéÀÌ ³·Àº °æÇâÀ» º¸¿´À¸³ª, Apo-B ¹× LeptinÀÇ ºñÀ²Àº ´ëÁ¶±ºÀ» ºñ·ÔÇÑ ¾¸¹Ù±ÍÃßÃâ¹° Åõ¿©±º µé °£¿¡ À¯ÀÇÇÑ Â÷À̸¦ ³ªÅ¸³»Áö´Â ¾Ê¾Ò´Ù. ÀÌ»óÀÇ °á°úµéÀ» Á¾ÇÕÇØº¸¸é, ¾¸¹Ù±Í ÃßÃâ¹°Àº ÁöÁú°­ÇÏ ¹× Ç×»êÈ­¿¡ ±àÁ¤ÀûÀÎ È¿°ú¸¦ ³ªÅ¸³»¾úÀ½À» ½Ã»çÇØÁØ´Ù.
To investigate effects of Ixeris dentata EtOH ext. on lowering lipid levels and anti-oxidation activity, hyperlipidemic rats were treated with Ixeris dentata EtOH ext. and lipid levels and anti-oxdation activity were measured. The Ixeris dentata EtOH ext. groups showed low concentration of plasma FFA, plasma triglyceride, plasma total cholesterol, and plasma LDL-cholesterol compared to control group. However, concentration of plasma HDLcholesterol was not significantly different among all the treatment groups. The Ixeris dentata EtOH ext. groups showed lower level of liver total cholesterol, liver triglyceride, plasma TBARS, and liver TBARS than those of control group. The Ixeris dentata EtOH ext. groups also showed higher level of GSH-Px activity, SOD activity, and CAT activity than those of control group. Moreover, the Ext. showed lower level of TNF-${alpha}$, Apo-B, Apo-E, and leptin expression than those of control group. The results in this study shows that the Ixeris dentata EtOH ext. have positive effect in lowering lipid level, and anti-oxidative activity.
 
Ű¿öµå
Ixeris dentata EtOH ext.;Lipid;TBARS;GSH-Px;TNF-${alpha}$;Apo-E;Leptin;
 
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸÁö / v.24, no.1, 2011³â, pp.55-60
Çѱ¹ÀÚ¿ø½Ä¹°ÇÐȸ
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO201116450097521)
¾ð¾î : Çѱ¹¾î
³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø
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