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한국자원식물학회 / v.24, no.3, 2011년, pp.324-329 
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( Inhibitory Effects of the Extracts from Eleutherococcus senticosus Maxim. on Histamine-release from Rat's Mast Cell ) |
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| 초 록 |
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| Eleutherococcus senticosus Maxim. has been successfully used as an oriental medicine for various diseases including allergic disorders. Histamine is a major factor on various allergic responses and it is reported that histamine was released from mast cells by sensitization of allergens. In this study, ethanol extracts from E. senticosus Maxim. were prepared and the composition was analyzed by high performance liquid chromatography. The eleutheroside B as a primary effective component of E. senticosus was contained approximately 225 mg/kg in root bark extracts. The extracts were found to significantly inhibit compound 48/80-induced histamine release form mast cells in dose dependent manner. However the extracts had low cytotoxicity on the mast cells with MTT assay. These results showed that E. senticosus Maxim. extracts may be the effective materials on inflammatory disorders. |
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| 키워드 |
| Eleutherococcus senticosus;Histamine;Mast cell;Eleutheroside;Root bark; |
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한국자원식물학회지 / v.24, no.3, 2011년, pp.324-329
한국자원식물학회
ISSN : 1226-3591
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO201122238509168)
언어 : 영어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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