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한국환경생물학회 / v.26, no.4, 2008년, pp.377-384 
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환경 스트레스에 의한 세포 내 신호의 이동 경로와 유전적 조절
( Genetic Regulation of Cellular Responses and Signal Targeting Pathways Invoked by an Environmental Stress ) |
| 김일섭;김현영;강홍규;윤호성; 경북대학교 생물학과;경북대학교 생물학과;제주대학교 아열대 원예산업 연구소;경북대학교 생물학과;
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| 초 록 |
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| A cell is the product of a long period of evolution and can be represented as an optimized system (homeostasis). Stimuli from the outside environment are received by sensory apparatus on the surface of the cell and transferred through complicated pathways and eventually regulate gene expression. These signals affect cell physiology, growth, and development, and the interaction among genes in the signal transduction pathway is a critical part of the regulation. In this study, the interactions of deletion mutants and overexpression of the extracopies of the genes were used to understand their relationships to each other. Also, green fluorescent protein (GFP reporter gene) was fused to the regulatory genes to elucidate their interactions. Cooverexpression of the two genes in extracopy plasmids suggested that patS acts at the downstream of hetR in the regulatory network. The experiments using gfp fusion in different genetic background cells also indicated the epistasis relationships between the two genes. A model describing the regulatory network that controls cell development is presented. |
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| 키워드 |
| signal targeting pathway;genetic epistasis;cellular development; |
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환경생물 / v.26, no.4, 2008년, pp.377-384
한국환경생물학회
ISSN : 1226-9999
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200820258463208)
언어 : 한국어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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