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한국환경생물학회 / v.20, no.1, 2002년, pp.35-39 
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( Cell Ploidy and Repair Ability Determine the Radioprotective Effects of Cysteamine in Yeast Cells of Various Species and Genotypes ) |
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| 초 록 |
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| The significance of cell ploidy and repair ability for the radioprotective efficiency of cysteamine was studied in DNA repair - proficient and repair - deficient yeast cells irradiated $^{60}C0;gamma-rays.$ Results have been obtained for the cell survival of two groups of yeasts-diplont and haplont cells, both in haploid and diploid states. For diploid Saccharomyces cerevisiae yeast cells, the correlation between the radio-protective action of cysteamine and the cell repair capacity was demonstrated. Such a correlation was not clearly expressed for haploid yeast cells. In addition, evidence was obtained indicating that the degree of the radioprotective action was independent of the number of chromosome sets in haplont yeast Pichia guilliermondii cells and in some radiosensitive mutants defective in the diploid-specific recovery. It is concluded on this basis that the radioprotective action may involve the cellular recovery process, which may be mediated by a recombination-like mechanism, for which the diploid state is required. The results obtained clearly show that the radioprotective effect was dependent on DNA repair status and indicate that the mechanism of the radioprotective action may be realized on the level of primary radiation damage production as well as on the level of postradiation recovery from potentially lethal radiation damage. |
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| 키워드 |
| radioprotective effect;ploidy;yeast cells;repair ability;evolution; |
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환경생물 / v.20, no.1, 2002년, pp.35-39
한국환경생물학회
ISSN : 1226-9999
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200211921492449)
언어 : 영어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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