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한국환경생물학회 / v.24, no.2, 2006년, pp.195-200 
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Formalin에 노출시킨 넙치 (Paralichthys olivaceus) 간장 약물대사효소의 in vivo 및 in vitro 반응
( In vitro and In vivo Responses of Hepatic Xenobiotic Metabolizing Enzymes in Flounder (Paralichthys olivaceus) Exposed to Formalin ) |
| 이지선;하진환;이경선;전중균; 강릉대학교 해양생명공학부/동해안해양생물자원연구센터;제주대학교 식품생명공학과;목포해양대학교 해양환경공학;강릉대학교 해양생명공학부/동해안해양생물자원연구센터;
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| 초 록 |
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| The response of hepatic mixed function oxygenase (MFO) system was investigated in olive flounder exposed to formalin. Hepatic microsome of olive flounder incubated in vitro with formalin demonstrated the induction of cytochrome P450 (CYP), ethoxyresorufin deethylase (EROD), cytochrome P450 reductase (P450R) and cytochrome b5 reductase (b5R) activity. In addition, olive flounder was exposed to 100, 300 and 500 ppm of formalin for 1 h and then transferred to a flow-through type of 1000 L aquarium. Hepatic MFO enzyme activity was determined for 72 h. As the result, hepatic CYP, P450R and EROD activities increased following exposure of formalin, but b5R and GST showed no significant change. These results imply that CYP and P450R can be considered as main hepatic enzymes involving in detoxification of formalin. |
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| 키워드 |
| formalin;in vivo; in vitro;cytochrome P450;cytochrome P450 reductase;EROD; |
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환경생물 / v.24, no.2, 2006년, pp.195-200
한국환경생물학회
ISSN : 1226-9999
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200629734084497)
언어 : 한국어 |
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| 논문 제공 : KISTI 한국과학기술정보연구원 |
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