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Çѱ¹»ý¹°È¯°æÁ¶ÀýÇÐȸ / v.18, no.1, 2009³â, pp.67-73
°õÃë ¸Þź¿Ã ÃßÃâ¹°ÀÇ »ý¸®È°¼º ¹× ¾Ï¼¼Æ÷ Áõ½Ä¾ïÁ¦ È¿°ú
( Physiological Activity of Methanol Extracts from Ligularia fischeri and Their Hyperplasia Inhibition Activity of Cancer Cell )
¹èÁ¾Çâ;À¯¼º¿À;±è¿µ¹Î;õ»ó¿í;±èº´¿î;ÇãºÏ±¸; ¿ø±¤´ëÇб³ ¿ø¿¹. ¾Ö¿Ïµ¿½Ä¹°ÇкÎ;¿ø±¤´ëÇб³ ¿ø¿¹. ¾Ö¿Ïµ¿½Ä¹°ÇкÎ;µ¿Àdzª¶ó(ÁÖ);(ÁÖ)ÀÌÆÄ¸®³Ý;¸ñÆ÷´ëÇб³ ¿ø¿¹°úÇаú;(Àç)³ªÁÖ½Ãõ¿¬¿°»ö¹®È­Àç´Ü;
 
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°õÃë(Ligularia fischeri)ÀÇ À̿뼺À» ³ôÀ̵¥ ÇÊ¿äÇÑ ±âÃÊÀڷḦ È®º¸ÇϰíÀÚ ¸Þź¿ÃÀ» ¿ë¸Å·Î ÇÏ¿© ÃßÃ⠿µµ ¹× ½Ã°£¿¡ µû¸¥ »ý¸®È°¼º È¿°ú¸¦ Á¶»çÇÏ¿´´Ù. °õÃë ¸Þź¿ÃÃßÃâ¹° $1,000mg{cdot}L^{-1}$¿¡ ÇÔÀ¯µÈ ÃÑ Æä³îÇÔ·®, ÃÑÇö󺸳ëÀ̵å ÇÔ·®Àº °¢°¢ $75.8-297.7mg{cdot}L^{-1}$ and $45.6-173.6mg{cdot}L^{-1}$À̾ú´Ù. ÃßÃâ¿Âµµ¿Í ½Ã°£Àº ÃÑ Æä³îÇÔ·®, ÃÑ Çö󺸳ëÀ̵å ÇÔ·®, ÀüÀÚ°ø¿© ´É ÀÇ °æ¿ì $95^{circ}C$¿¡¼­ 6½Ã°£ µ¿¾È ÃßÃâÇßÀ» ¶§ °¡Àå ÁÁ¾Ò´Ù. ±×·¯³ª ¾ÆÁú»ê¿° ¼Ò°Å´ÉÀº $75^{circ}C$¿¡¼­ 12½Ã°£ ÃßÃâÇÑ °Í¿¡¼­ 97.4%·Î °¡Àå ³ô°Ô ³ªÅ¸³µ´Ù. °õÃë ¸ÞźÀ» ÃßÃâ¹° $200mg{cdot}L^{-1}$ ¹× $400mg{cdot}L^{-1}$ ³óµµ´Â °¢°¢ Æó¾Ï°ú À§¾Ï¼¼Æ÷ Áõ½ÄÀ» 90% ÀÌ»ó ¾ïÁ¦½ÃÄ×´Ù. µû¶ó¼­ °õÃë´Â ³ôÀº »ý¸®È°¼º ±â´ÉÀ» ³ªÅ¸³»´Â ä¼Ò·Î ³ªÅ¸³µÀ¸¸ç, °õÃ븦 °¡°øÇ°À¸·Î ÀÌ¿ëÇϱâ À§ÇØ ¸Þź¿Ã·Î ÃßÃâÇÒ ¶§´Â $95^{circ}C$¿¡¼­ 6½Ã°£ Á¤µµ ÇÏ´Â °ÍÀÌ ÁÁÀ» °ÍÀ¸·Î »ý°¢µÇ¾ú´Ù.
This study was conducted to gather the basic data on making good use of a kind of groundsel (Ligularia fischeri). We have made methanol extracts from Ligularia fischeri and have also determined the effects of extracting temperature and time on the physiological activities of methanol extracts from Ligularia fischeri. Total phenolic compound and flavonoid contents in the methanol extracts from Ligularia fischeri at the extracting concentration of $1,000mg{cdot}L^{-1}$ were $75.8-297.7mg{cdot}L^{-1}$ and $45.6-173.6mg{cdot}L^{-1}$. Total phenolic compound and flavonoid contents, and DPPH radical scavenging activities were most increased when Ligularia fischeri was extracted with methanol at $95^{circ}C$ for 6 hours, however, nitrite radical scavenging activities were extremely increased at $75^{circ}C$ for 12 hours by 97.4%. At $200mg{cdot}L^{-1}$ and $400mg{cdot}L^{-1}$ methanol extracting concentration, the hyperplasia of lung cancer cells (Calu-6) and stomach cancer cells (SNU601) were effectively inhibited over 90%. Consequently, it was assumed that Ligularia fischeri was a functional vegetable with a higher physiological activities. Making the processed foods, it had better make the extracts from Ligularia fischeri with methanol at $95^{circ}C$ for 6 hours.
 
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DPPH ÀÚÀ¯¶óµðÄà ¼Ò°Å´É·Â;¾ÆÁú»ê¿° ¼Ò°Å´É·Â;ÃÑ Çö󺸳ëÀ̵åÇÔ·®;ÃÑ Æä³îÇÔ·®;Ç×¾Ï;anticancer;DPPH radical scavenging activity;nitrite radical scavenging activity;total flavonoid content;total phenolic compound content;
 
»ý¹°È¯°æÁ¶ÀýÇÐȸÁö / v.18, no.1, 2009³â, pp.67-73
Çѱ¹»ý¹°È¯°æÁ¶ÀýÇÐȸ
ISSN : 1229-4675
UCI : G100:I100-KOI(KISTI1.1003/JNL.JAKO200916263468259)
¾ð¾î : Çѱ¹¾î
³í¹® Á¦°ø : KISTI Çѱ¹°úÇбâ¼úÁ¤º¸¿¬±¸¿ø
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